It's a distinction that doesn't matter. What matters is does our body know what to do useful with the chemical, does the chemical mingle in negative ways with our normal pathways, does the chemical mingle in negative ways witht he pathways of nature we rely on for health and whether we know any of this before releasing the chemical both individually and along with all other chemicals we release or are we playing an open air science experiment without informed consent or any sense of precautionary principle.